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Seok-Geun Lee Selected Research

Cytokines

2/2018Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells.
1/2018Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo.
2/2017Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis.
2/2013Proinflammatory cytokine IL-1 β polymorphisms in sudden sensorineural hearing loss.
10/2010mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
5/2010Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
11/2007mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

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Seok-Geun Lee Research Topics

Disease

42Neoplasms (Cancer)
12/2021 - 11/2006
11Neoplasm Metastasis (Metastasis)
10/2021 - 12/2011
9Inflammation (Inflammations)
09/2020 - 01/2005
9Prostatic Neoplasms (Prostate Cancer)
01/2017 - 03/2010
8Melanoma (Melanoma, Malignant)
01/2019 - 11/2007
6Glioma (Gliomas)
02/2016 - 05/2007
5Carcinogenesis
02/2018 - 11/2006
5Multiple Myeloma
01/2018 - 03/2011
4Lung Neoplasms (Lung Cancer)
12/2021 - 05/2016
4Infections
07/2021 - 03/2010
4Breast Neoplasms (Breast Cancer)
06/2021 - 12/2011
2Colonic Neoplasms (Colon Cancer)
10/2021 - 01/2019
2Colorectal Neoplasms (Colorectal Cancer)
10/2021 - 01/2019
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
07/2021 - 07/2015
2Fever (Fevers)
10/2020 - 02/2018
2Hypoxia (Hypoxemia)
03/2020 - 12/2009
2Alzheimer Disease (Alzheimer's Disease)
01/2020 - 10/2011
2Seizures (Absence Seizure)
11/2019 - 03/2015
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2018 - 05/2016
2Carcinoma (Carcinomatosis)
11/2018 - 02/2012
2Cough
06/2018 - 02/2018
2B-Cell Lymphoma (Lymphoma, B Cell)
06/2017 - 07/2015
2Hepatocellular Carcinoma (Hepatoma)
05/2017 - 01/2011
2Glioblastoma (Glioblastoma Multiforme)
11/2016 - 02/2016
2Type 2 Diabetes Mellitus (MODY)
10/2016 - 01/2016
2Neurodegenerative Diseases (Neurodegenerative Disease)
10/2011 - 05/2008
1Toxoplasmosis
07/2021
1Parasitic Diseases (Parasitic Disease)
07/2021
1HIV Infections (HIV Infection)
07/2021
1Liposarcoma
06/2021
1Arthralgia (Joint Pain)
10/2020
1Arthritis (Polyarthritis)
10/2020
1Headache (Headaches)
10/2020
1Nervous System Diseases (Neurological Disorders)
09/2020
1Ischemia
11/2019
1Brain Diseases (Brain Disorder)
11/2019
1Adenocarcinoma of Lung
06/2019
1Sleep Wake Disorders
06/2018
1Pain (Aches)
06/2018

Drug/Important Bio-Agent (IBA)

13Proteins (Proteins, Gene)FDA Link
06/2021 - 11/2009
9STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
12/2021 - 03/2011
7CytokinesIBA
02/2018 - 11/2007
6InterleukinsIBA
05/2012 - 11/2007
5morusinIBA
09/2020 - 01/2015
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2019 - 04/2014
4embelinIBA
01/2018 - 09/2011
4Mitogen-Activated Protein KinasesIBA
07/2017 - 12/2011
4SurvivinIBA
06/2017 - 12/2011
3Biomarkers (Surrogate Marker)IBA
12/2021 - 02/2013
3Phosphotransferases (Kinase)IBA
01/2020 - 03/2011
3Transcription Factors (Transcription Factor)IBA
02/2017 - 01/2013
3Interleukin-10 (Interleukin 10)IBA
05/2012 - 05/2010
3Glutamic Acid (Glutamate)FDA Link
10/2011 - 05/2008
3CeramidesIBA
09/2011 - 03/2010
3Small Interfering RNA (siRNA)IBA
01/2010 - 05/2007
2Mechanistic Target of Rapamycin Complex 1IBA
12/2021 - 03/2015
2ginkgolide CIBA
12/2021 - 10/2021
2LipopolysaccharidesIBA
06/2020 - 04/2019
2Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2020 - 03/2015
2Conditioned Culture MediaIBA
01/2020 - 01/2019
2GlycosidesIBA
11/2018 - 02/2018
2ophiopogonin DIBA
11/2018 - 02/2018
2ginkgolic acidIBA
02/2017 - 02/2017
2Pharmaceutical PreparationsIBA
01/2017 - 01/2015
2LigandsIBA
05/2016 - 02/2016
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2015 - 12/2011
2Cyclin D1IBA
07/2015 - 12/2011
2TOR Serine-Threonine KinasesIBA
03/2015 - 03/2012
2Therapeutic UsesIBA
12/2014 - 01/2013
2caryophyllene oxideIBA
04/2014 - 12/2011
2Lysine (L-Lysine)FDA Link
01/2013 - 04/2011
2CEACAM1 ProteinIBA
01/2013 - 04/2011
2CalpainIBA
09/2011 - 05/2010
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
12/2009 - 11/2006
2NF-kappa B (NF-kB)IBA
03/2008 - 05/2007
1Ribosomal Protein S6IBA
12/2021
1CateninsIBA
10/2021
1Pyrimethamine (Daraprim)FDA Link
07/2021
1Histones (Histone)IBA
06/2021
1NucleolinIBA
06/2021
1Tolonium ChlorideFDA Link
10/2020
1safranine T (safranin)IBA
10/2020
1Eosine Yellowish-(YS) (Eosin)IBA
10/2020
1Hematoxylin (Haematoxylon)IBA
10/2020
1kumi-kyokatsu-toIBA
10/2020
1TabletsIBA
10/2020
1potassium channel protein TREK-1IBA
03/2020
1dactolisibIBA
01/2020
1Ciliary Neurotrophic Factor (CNTF)IBA
01/2020
1Glial Fibrillary Acidic ProteinIBA
01/2020
1Interleukin-6 (Interleukin 6)IBA
01/2020
1PotassiumIBA
11/2019
1Glutathione Disulfide (GSSG)FDA LinkGeneric
11/2018
1Hypnotics and Sedatives (Sedatives)IBA
06/2018
1Paclitaxel (Taxol)FDA LinkGeneric
02/2018
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
02/2018
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
02/2018
1IsoflavonesIBA
01/2018

Therapy/Procedure

13Therapeutics
11/2018 - 11/2007
3Drug Therapy (Chemotherapy)
12/2012 - 11/2007